AbbVie Bioresearch Corporation

Antibody Conjugation Facility

Project at a Glance
Location

Worcester, MA

Architect

Jacobs

Market

Life Sciences

Project Type

Renovation

Project Overview

  • Construction was performed in vicinity of ISO 7 clean rooms
  • Significant Process Piping, Qualified Controls, and Mechanical upgrades to support product development with high hazardous materials
  • Repurposed three decontamination tanks for removal of potent waste from within the facility to a truck loadout station on the exterior façade

AbbVie decided to grow their facility’s capabilities by renovating an existing production suite and creating an Antibody Conjugation Facility. The project demanded major mechanical upgrades to support the need for working with highly-potent compounds while maintaining a safe working environment. The scope included the installation of multiple independent HEPA air filtration units designed to isolate hazardous compounds in the environment and provide localized control of elements in the workspace.

Additionally, the project included the installation of a mist booth, bioreactor, biosafety cabinet, and isolator. In order to support the new equipment, several new validated & non-validated utilities, such as clean steam, glycol, nitrogen and IA/PA, were piped to panels in the room. Structural modifications were completed to create an ISO 5 airlocks with a purposeful flow of equipment and personnel into the Suite.

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